{"id":110,"date":"2019-02-22T10:11:22","date_gmt":"2019-02-22T09:11:22","guid":{"rendered":"https:\/\/transfer.sysepi.medizin.uni-greifswald.de\/thyroidomics\/?page_id=110"},"modified":"2019-07-04T15:32:44","modified_gmt":"2019-07-04T13:32:44","slug":"associations","status":"publish","type":"page","link":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/associations\/","title":{"rendered":"Genetic Associations"},"content":{"rendered":"\n

Genome-wide significant GWAS associations of the Teumer et al.<\/em> (Nat Commun., 2018) dataset for the free T4 and TSH levels with the corresponding association results of additional traits added. The TPOab-positivity results are from the Medici et al.<\/em> (PLoS Genetics, 2014) publication.<\/p>\n\n\n\n

\n\n\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
TSH<\/b><\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/tr>\n
SNP<\/td>\n Chr<\/td>\n Position (hg19)<\/td>\n Nearest Gene<\/td>\n A1<\/td>\n A2<\/td>\n BETA<\/td>\n SE<\/td>\n P<\/td>\n BETA FT4<\/td>\n SE FT4<\/td>\n P FT4<\/td>\n BETA hyperthyroidism<\/td>\n SE hyperthyroidism<\/td>\n P hyperthyroidism<\/td>\n BETA hypothyroidism<\/td>\n SE hypothyroidism<\/td>\n P hypothyroidism<\/td>\n BETA TPOab-positivity<\/td>\n SE TPOab-positivity<\/td>\n P TPOab-positivity<\/td>\n <\/tr>\n
rs12089835<\/td>\n 1<\/td>\n 19,771,438<\/td>\n CAPZB<\/td>\n t<\/td>\n c<\/td>\n 0.073<\/td>\n 0.007<\/td>\n 1.27E-28<\/td>\n -0.017<\/td>\n 0.007<\/td>\n 1.41E-02<\/td>\n -0.110<\/td>\n 0.033<\/td>\n 7.74E-04<\/td>\n 0.129<\/td>\n 0.027<\/td>\n 1.43E-06<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10917469<\/td>\n 1<\/td>\n 19,843,576<\/td>\n CAPZB<\/td>\n a<\/td>\n g<\/td>\n 0.111<\/td>\n 0.009<\/td>\n 3.95E-39<\/td>\n -0.029<\/td>\n 0.009<\/td>\n 1.17E-03<\/td>\n -0.227<\/td>\n 0.040<\/td>\n 1.01E-08<\/td>\n 0.234<\/td>\n 0.037<\/td>\n 1.90E-10<\/td>\n -0.002<\/td>\n 0.047<\/td>\n 9.74E-01<\/td>\n <\/tr>\n
rs74804879<\/td>\n 1<\/td>\n 19,862,320<\/td>\n CAPZB<\/td>\n t<\/td>\n c<\/td>\n 0.050<\/td>\n 0.007<\/td>\n 1.22E-14<\/td>\n -0.015<\/td>\n 0.007<\/td>\n 3.31E-02<\/td>\n -0.111<\/td>\n 0.033<\/td>\n 6.92E-04<\/td>\n 0.095<\/td>\n 0.027<\/td>\n 3.71E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs334725<\/td>\n 1<\/td>\n 61,610,049<\/td>\n NFIA<\/td>\n a<\/td>\n g<\/td>\n 0.174<\/td>\n 0.015<\/td>\n 2.45E-32<\/td>\n -0.058<\/td>\n 0.015<\/td>\n 1.08E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n -0.027<\/td>\n 0.083<\/td>\n 7.45E-01<\/td>\n <\/tr>\n
rs17020122<\/td>\n 1<\/td>\n 108,357,391<\/td>\n VAV3<\/td>\n t<\/td>\n c<\/td>\n 0.104<\/td>\n 0.011<\/td>\n 5.32E-20<\/td>\n -0.017<\/td>\n 0.012<\/td>\n 1.40E-01<\/td>\n -0.105<\/td>\n 0.065<\/td>\n 1.08E-01<\/td>\n 0.311<\/td>\n 0.042<\/td>\n 6.56E-14<\/td>\n 0.168<\/td>\n 0.058<\/td>\n 3.54E-03<\/td>\n <\/tr>\n
rs16856540<\/td>\n 2<\/td>\n 217,580,413<\/td>\n IGFBP5<\/td>\n t<\/td>\n c<\/td>\n -0.055<\/td>\n 0.008<\/td>\n 7.81E-11<\/td>\n 0.005<\/td>\n 0.009<\/td>\n 6.06E-01<\/td>\n 0.147<\/td>\n 0.043<\/td>\n 6.81E-04<\/td>\n -0.009<\/td>\n 0.034<\/td>\n 8.00E-01<\/td>\n 0.065<\/td>\n 0.049<\/td>\n 1.79E-01<\/td>\n <\/tr>\n
rs13015993<\/td>\n 2<\/td>\n 217,625,523<\/td>\n IGFBP5<\/td>\n a<\/td>\n g<\/td>\n 0.082<\/td>\n 0.007<\/td>\n 4.52E-32<\/td>\n -0.016<\/td>\n 0.008<\/td>\n 4.41E-02<\/td>\n -0.171<\/td>\n 0.034<\/td>\n 3.48E-07<\/td>\n 0.055<\/td>\n 0.029<\/td>\n 5.40E-02<\/td>\n -0.084<\/td>\n 0.036<\/td>\n 2.12E-02<\/td>\n <\/tr>\n
rs6724073<\/td>\n 2<\/td>\n 218,236,786<\/td>\n DIRC3<\/td>\n t<\/td>\n c<\/td>\n 0.051<\/td>\n 0.008<\/td>\n 1.35E-10<\/td>\n -0.024<\/td>\n 0.009<\/td>\n 5.04E-03<\/td>\n -0.065<\/td>\n 0.040<\/td>\n 1.06E-01<\/td>\n 0.061<\/td>\n 0.033<\/td>\n 6.34E-02<\/td>\n -0.222<\/td>\n 0.065<\/td>\n 6.06E-04<\/td>\n <\/tr>\n
rs1663070<\/td>\n 3<\/td>\n 12,239,852<\/td>\n SYN2<\/td>\n t<\/td>\n c<\/td>\n -0.046<\/td>\n 0.007<\/td>\n 3.49E-11<\/td>\n -0.001<\/td>\n 0.007<\/td>\n 8.93E-01<\/td>\n 0.055<\/td>\n 0.036<\/td>\n 1.32E-01<\/td>\n -0.083<\/td>\n 0.028<\/td>\n 3.14E-03<\/td>\n 0.006<\/td>\n 0.039<\/td>\n 8.85E-01<\/td>\n <\/tr>\n
rs28502438<\/td>\n 3<\/td>\n 149,220,109<\/td>\n TM4SF4<\/td>\n t<\/td>\n c<\/td>\n 0.034<\/td>\n 0.006<\/td>\n 3.70E-08<\/td>\n -0.009<\/td>\n 0.007<\/td>\n 1.82E-01<\/td>\n -0.010<\/td>\n 0.032<\/td>\n 7.58E-01<\/td>\n 0.046<\/td>\n 0.025<\/td>\n 7.15E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs13100823<\/td>\n 3<\/td>\n 185,514,088<\/td>\n IGF2BP2<\/td>\n t<\/td>\n c<\/td>\n -0.041<\/td>\n 0.007<\/td>\n 6.76E-10<\/td>\n 0.021<\/td>\n 0.007<\/td>\n 3.39E-03<\/td>\n 0.110<\/td>\n 0.033<\/td>\n 8.55E-04<\/td>\n -0.104<\/td>\n 0.028<\/td>\n 1.67E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs59381142<\/td>\n 3<\/td>\n 193,916,181<\/td>\n HES1<\/td>\n a<\/td>\n g<\/td>\n -0.058<\/td>\n 0.008<\/td>\n 1.70E-14<\/td>\n 0.007<\/td>\n 0.008<\/td>\n 3.49E-01<\/td>\n 0.114<\/td>\n 0.036<\/td>\n 1.77E-03<\/td>\n -0.070<\/td>\n 0.031<\/td>\n 2.38E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs6535624<\/td>\n 4<\/td>\n 149,587,905<\/td>\n NR3C2<\/td>\n a<\/td>\n g<\/td>\n 0.042<\/td>\n 0.006<\/td>\n 1.60E-11<\/td>\n -0.006<\/td>\n 0.007<\/td>\n 3.87E-01<\/td>\n -0.093<\/td>\n 0.032<\/td>\n 3.39E-03<\/td>\n 0.055<\/td>\n 0.025<\/td>\n 2.84E-02<\/td>\n 0.065<\/td>\n 0.031<\/td>\n 3.31E-02<\/td>\n <\/tr>\n
rs11732089<\/td>\n 4<\/td>\n 149,665,602<\/td>\n NR3C2<\/td>\n t<\/td>\n c<\/td>\n 0.115<\/td>\n 0.008<\/td>\n 1.73E-51<\/td>\n 0.005<\/td>\n 0.008<\/td>\n 5.67E-01<\/td>\n -0.176<\/td>\n 0.037<\/td>\n 1.73E-06<\/td>\n 0.133<\/td>\n 0.032<\/td>\n 2.84E-05<\/td>\n 0.064<\/td>\n 0.042<\/td>\n 1.28E-01<\/td>\n <\/tr>\n
rs62362610<\/td>\n 5<\/td>\n 76,439,961<\/td>\n ZBED3-AS1<\/td>\n c<\/td>\n g<\/td>\n 0.073<\/td>\n 0.012<\/td>\n 7.73E-10<\/td>\n -0.018<\/td>\n 0.013<\/td>\n 1.54E-01<\/td>\n -0.168<\/td>\n 0.067<\/td>\n 1.27E-02<\/td>\n 0.084<\/td>\n 0.047<\/td>\n 7.50E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1119208<\/td>\n 5<\/td>\n 76,488,613<\/td>\n PDE8B<\/td>\n t<\/td>\n c<\/td>\n 0.046<\/td>\n 0.006<\/td>\n 6.65E-13<\/td>\n -0.010<\/td>\n 0.007<\/td>\n 1.50E-01<\/td>\n -0.135<\/td>\n 0.033<\/td>\n 4.91E-05<\/td>\n -0.002<\/td>\n 0.026<\/td>\n 9.54E-01<\/td>\n -0.031<\/td>\n 0.033<\/td>\n 3.43E-01<\/td>\n <\/tr>\n
rs139424329<\/td>\n 5<\/td>\n 76,495,539<\/td>\n PDE8B<\/td>\n a<\/td>\n g<\/td>\n -0.200<\/td>\n 0.032<\/td>\n 5.14E-10<\/td>\n 0.019<\/td>\n 0.034<\/td>\n 5.74E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs2127387<\/td>\n 5<\/td>\n 76,532,571<\/td>\n PDE8B<\/td>\n a<\/td>\n g<\/td>\n 0.144<\/td>\n 0.006<\/td>\n 1.10E-117<\/td>\n -0.032<\/td>\n 0.007<\/td>\n 2.07E-06<\/td>\n -0.328<\/td>\n 0.034<\/td>\n 4.92E-22<\/td>\n 0.150<\/td>\n 0.026<\/td>\n 4.24E-09<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs7702192<\/td>\n 5<\/td>\n 76,554,807<\/td>\n PDE8B<\/td>\n a<\/td>\n c<\/td>\n 0.070<\/td>\n 0.006<\/td>\n 2.61E-30<\/td>\n -0.012<\/td>\n 0.007<\/td>\n 5.84E-02<\/td>\n -0.169<\/td>\n 0.033<\/td>\n 2.79E-07<\/td>\n 0.075<\/td>\n 0.026<\/td>\n 3.65E-03<\/td>\n 0.048<\/td>\n 0.028<\/td>\n 8.68E-02<\/td>\n <\/tr>\n
rs113974964<\/td>\n 5<\/td>\n 76,652,403<\/td>\n PDE8B<\/td>\n t<\/td>\n c<\/td>\n -0.124<\/td>\n 0.015<\/td>\n 2.06E-17<\/td>\n 0.019<\/td>\n 0.016<\/td>\n 2.24E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs139149784<\/td>\n 5<\/td>\n 76,660,193<\/td>\n PDE8B<\/td>\n a<\/td>\n g<\/td>\n 0.156<\/td>\n 0.029<\/td>\n 4.97E-08<\/td>\n 0.001<\/td>\n 0.030<\/td>\n 9.79E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs182873197<\/td>\n 5<\/td>\n 76,773,148<\/td>\n WDR41<\/td>\n t<\/td>\n c<\/td>\n -0.080<\/td>\n 0.014<\/td>\n 1.71E-08<\/td>\n 0.013<\/td>\n 0.015<\/td>\n 4.10E-01<\/td>\n 0.086<\/td>\n 0.074<\/td>\n 2.45E-01<\/td>\n -0.079<\/td>\n 0.061<\/td>\n 1.93E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1265091<\/td>\n 6<\/td>\n 31,108,129<\/td>\n PSORS1C1<\/td>\n t<\/td>\n c<\/td>\n 0.057<\/td>\n 0.009<\/td>\n 3.20E-11<\/td>\n -0.019<\/td>\n 0.009<\/td>\n 4.67E-02<\/td>\n -0.043<\/td>\n 0.042<\/td>\n 3.04E-01<\/td>\n 0.072<\/td>\n 0.033<\/td>\n 3.03E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs744103<\/td>\n 6<\/td>\n 43,805,362<\/td>\n VEGFA<\/td>\n a<\/td>\n t<\/td>\n 0.092<\/td>\n 0.007<\/td>\n 6.73E-41<\/td>\n -0.030<\/td>\n 0.007<\/td>\n 3.12E-05<\/td>\n -0.142<\/td>\n 0.034<\/td>\n 3.66E-05<\/td>\n 0.116<\/td>\n 0.029<\/td>\n 5.71E-05<\/td>\n -0.015<\/td>\n 0.049<\/td>\n 7.67E-01<\/td>\n <\/tr>\n
rs9381266<\/td>\n 6<\/td>\n 43,905,037<\/td>\n LOC100132354<\/td>\n t<\/td>\n c<\/td>\n 0.073<\/td>\n 0.007<\/td>\n 1.84E-25<\/td>\n -0.021<\/td>\n 0.008<\/td>\n 5.78E-03<\/td>\n -0.184<\/td>\n 0.035<\/td>\n 1.54E-07<\/td>\n 0.086<\/td>\n 0.029<\/td>\n 3.23E-03<\/td>\n -0.045<\/td>\n 0.038<\/td>\n 2.37E-01<\/td>\n <\/tr>\n
rs9497965<\/td>\n 6<\/td>\n 148,521,292<\/td>\n SASH1<\/td>\n t<\/td>\n c<\/td>\n 0.044<\/td>\n 0.006<\/td>\n 9.81E-13<\/td>\n -0.007<\/td>\n 0.007<\/td>\n 3.32E-01<\/td>\n -0.029<\/td>\n 0.032<\/td>\n 3.52E-01<\/td>\n 0.109<\/td>\n 0.025<\/td>\n 1.61E-05<\/td>\n 0.035<\/td>\n 0.030<\/td>\n 2.55E-01<\/td>\n <\/tr>\n
rs73022105<\/td>\n 6<\/td>\n 165,973,757<\/td>\n PDE10A<\/td>\n t<\/td>\n c<\/td>\n 0.105<\/td>\n 0.016<\/td>\n 1.20E-11<\/td>\n -0.014<\/td>\n 0.017<\/td>\n 4.09E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1079418<\/td>\n 6<\/td>\n 166,047,034<\/td>\n PDE10A<\/td>\n a<\/td>\n g<\/td>\n 0.101<\/td>\n 0.007<\/td>\n 8.23E-53<\/td>\n -0.017<\/td>\n 0.007<\/td>\n 1.80E-02<\/td>\n -0.191<\/td>\n 0.032<\/td>\n 3.68E-09<\/td>\n 0.151<\/td>\n 0.028<\/td>\n 4.17E-08<\/td>\n -0.059<\/td>\n 0.034<\/td>\n 8.26E-02<\/td>\n <\/tr>\n
rs56009477<\/td>\n 8<\/td>\n 23,356,964<\/td>\n SLC25A37<\/td>\n a<\/td>\n g<\/td>\n 0.052<\/td>\n 0.008<\/td>\n 3.72E-10<\/td>\n -0.016<\/td>\n 0.009<\/td>\n 8.50E-02<\/td>\n -0.107<\/td>\n 0.041<\/td>\n 9.09E-03<\/td>\n 0.077<\/td>\n 0.036<\/td>\n 3.51E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs2439301<\/td>\n 8<\/td>\n 32,433,013<\/td>\n NRG1<\/td>\n a<\/td>\n g<\/td>\n -0.059<\/td>\n 0.008<\/td>\n 8.15E-15<\/td>\n 0.008<\/td>\n 0.008<\/td>\n 3.06E-01<\/td>\n 0.101<\/td>\n 0.038<\/td>\n 7.97E-03<\/td>\n -0.066<\/td>\n 0.031<\/td>\n 3.47E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10957494<\/td>\n 8<\/td>\n 70,365,025<\/td>\n SULF1<\/td>\n a<\/td>\n g<\/td>\n -0.040<\/td>\n 0.007<\/td>\n 1.10E-09<\/td>\n 0.009<\/td>\n 0.007<\/td>\n 2.20E-01<\/td>\n 0.071<\/td>\n 0.034<\/td>\n 3.53E-02<\/td>\n -0.031<\/td>\n 0.027<\/td>\n 2.52E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs118039499<\/td>\n 8<\/td>\n 133,771,635<\/td>\n TMEM71<\/td>\n a<\/td>\n c<\/td>\n 0.184<\/td>\n 0.024<\/td>\n 1.99E-14<\/td>\n -0.021<\/td>\n 0.025<\/td>\n 4.02E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs2739067<\/td>\n 8<\/td>\n 133,951,991<\/td>\n TG<\/td>\n a<\/td>\n g<\/td>\n -0.042<\/td>\n 0.006<\/td>\n 2.43E-11<\/td>\n 0.015<\/td>\n 0.007<\/td>\n 2.72E-02<\/td>\n 0.050<\/td>\n 0.032<\/td>\n 1.20E-01<\/td>\n -0.038<\/td>\n 0.025<\/td>\n 1.28E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10814915<\/td>\n 9<\/td>\n 4,290,544<\/td>\n GLIS3<\/td>\n t<\/td>\n c<\/td>\n 0.042<\/td>\n 0.006<\/td>\n 5.06E-12<\/td>\n -0.027<\/td>\n 0.007<\/td>\n 5.94E-05<\/td>\n -0.115<\/td>\n 0.032<\/td>\n 3.14E-04<\/td>\n 0.077<\/td>\n 0.025<\/td>\n 2.50E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs9298749<\/td>\n 9<\/td>\n 16,214,340<\/td>\n C9orf92<\/td>\n a<\/td>\n c<\/td>\n -0.039<\/td>\n 0.006<\/td>\n 8.80E-10<\/td>\n 0.014<\/td>\n 0.007<\/td>\n 3.96E-02<\/td>\n -0.004<\/td>\n 0.033<\/td>\n 8.96E-01<\/td>\n -0.070<\/td>\n 0.026<\/td>\n 6.96E-03<\/td>\n -0.013<\/td>\n 0.033<\/td>\n 6.88E-01<\/td>\n <\/tr>\n
rs8176645<\/td>\n 9<\/td>\n 136,149,098<\/td>\n ABO<\/td>\n a<\/td>\n t<\/td>\n 0.052<\/td>\n 0.006<\/td>\n 3.93E-16<\/td>\n -0.002<\/td>\n 0.007<\/td>\n 8.05E-01<\/td>\n -0.077<\/td>\n 0.033<\/td>\n 2.08E-02<\/td>\n 0.094<\/td>\n 0.026<\/td>\n 2.28E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs11255790<\/td>\n 10<\/td>\n 8,682,180<\/td>\n GATA3<\/td>\n t<\/td>\n c<\/td>\n -0.041<\/td>\n 0.007<\/td>\n 6.83E-10<\/td>\n 0.007<\/td>\n 0.007<\/td>\n 3.53E-01<\/td>\n 0.083<\/td>\n 0.034<\/td>\n 1.34E-02<\/td>\n -0.007<\/td>\n 0.027<\/td>\n 7.89E-01<\/td>\n -0.017<\/td>\n 0.034<\/td>\n 6.18E-01<\/td>\n <\/tr>\n
rs4933466<\/td>\n 10<\/td>\n 89,849,519<\/td>\n PTEN<\/td>\n a<\/td>\n g<\/td>\n 0.040<\/td>\n 0.006<\/td>\n 5.13E-10<\/td>\n -0.015<\/td>\n 0.007<\/td>\n 2.84E-02<\/td>\n -0.037<\/td>\n 0.033<\/td>\n 2.63E-01<\/td>\n 0.072<\/td>\n 0.027<\/td>\n 6.72E-03<\/td>\n 0.008<\/td>\n 0.032<\/td>\n 8.09E-01<\/td>\n <\/tr>\n
rs200574439<\/td>\n 10<\/td>\n 101,283,330<\/td>\n NKX2-3<\/td>\n a<\/td>\n c<\/td>\n -0.047<\/td>\n 0.006<\/td>\n 3.69E-13<\/td>\n 0.019<\/td>\n 0.007<\/td>\n 6.73E-03<\/td>\n 0.141<\/td>\n 0.034<\/td>\n 3.20E-05<\/td>\n -0.101<\/td>\n 0.027<\/td>\n 1.36E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs12284404<\/td>\n 11<\/td>\n 45,228,686<\/td>\n PRDM11<\/td>\n a<\/td>\n g<\/td>\n -0.067<\/td>\n 0.007<\/td>\n 2.48E-22<\/td>\n 0.006<\/td>\n 0.007<\/td>\n 4.17E-01<\/td>\n 0.232<\/td>\n 0.035<\/td>\n 5.94E-11<\/td>\n 0.002<\/td>\n 0.029<\/td>\n 9.53E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs4445669<\/td>\n 11<\/td>\n 115,045,237<\/td>\n CADM1<\/td>\n t<\/td>\n c<\/td>\n -0.040<\/td>\n 0.006<\/td>\n 5.76E-11<\/td>\n 0.009<\/td>\n 0.007<\/td>\n 1.57E-01<\/td>\n 0.064<\/td>\n 0.033<\/td>\n 5.10E-02<\/td>\n -0.042<\/td>\n 0.025<\/td>\n 9.45E-02<\/td>\n 0.004<\/td>\n 0.029<\/td>\n 8.99E-01<\/td>\n <\/tr>\n
rs7329958<\/td>\n 13<\/td>\n 24,782,080<\/td>\n SPATA13<\/td>\n t<\/td>\n c<\/td>\n -0.044<\/td>\n 0.007<\/td>\n 1.13E-11<\/td>\n 0.011<\/td>\n 0.007<\/td>\n 1.39E-01<\/td>\n 0.017<\/td>\n 0.034<\/td>\n 6.11E-01<\/td>\n -0.079<\/td>\n 0.028<\/td>\n 4.48E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs398745<\/td>\n 14<\/td>\n 36,536,181<\/td>\n LINC00609<\/td>\n a<\/td>\n c<\/td>\n -0.052<\/td>\n 0.006<\/td>\n 3.97E-17<\/td>\n 0.025<\/td>\n 0.007<\/td>\n 1.72E-04<\/td>\n 0.102<\/td>\n 0.033<\/td>\n 1.72E-03<\/td>\n -0.058<\/td>\n 0.025<\/td>\n 2.14E-02<\/td>\n 0.012<\/td>\n 0.030<\/td>\n 6.81E-01<\/td>\n <\/tr>\n
rs2254613<\/td>\n 14<\/td>\n 36,713,154<\/td>\n MBIP<\/td>\n t<\/td>\n g<\/td>\n -0.035<\/td>\n 0.006<\/td>\n 3.44E-08<\/td>\n 0.018<\/td>\n 0.007<\/td>\n 8.12E-03<\/td>\n 0.073<\/td>\n 0.032<\/td>\n 2.40E-02<\/td>\n -0.021<\/td>\n 0.026<\/td>\n 4.18E-01<\/td>\n 0.010<\/td>\n 0.043<\/td>\n 8.22E-01<\/td>\n <\/tr>\n
rs11159482<\/td>\n 14<\/td>\n 81,490,842<\/td>\n TSHR<\/td>\n t<\/td>\n c<\/td>\n 0.085<\/td>\n 0.013<\/td>\n 6.30E-11<\/td>\n -0.018<\/td>\n 0.014<\/td>\n 2.09E-01<\/td>\n -0.093<\/td>\n 0.071<\/td>\n 1.89E-01<\/td>\n 0.191<\/td>\n 0.051<\/td>\n 1.82E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs59334515<\/td>\n 14<\/td>\n 81,594,143<\/td>\n TSHR<\/td>\n t<\/td>\n c<\/td>\n -0.054<\/td>\n 0.007<\/td>\n 1.10E-13<\/td>\n -0.014<\/td>\n 0.008<\/td>\n 8.12E-02<\/td>\n 0.095<\/td>\n 0.038<\/td>\n 1.37E-02<\/td>\n -0.093<\/td>\n 0.031<\/td>\n 3.06E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs12893151<\/td>\n 14<\/td>\n 81,619,945<\/td>\n TSHR<\/td>\n a<\/td>\n c<\/td>\n -0.062<\/td>\n 0.008<\/td>\n 1.02E-15<\/td>\n -0.001<\/td>\n 0.008<\/td>\n 9.34E-01<\/td>\n 0.142<\/td>\n 0.040<\/td>\n 3.24E-04<\/td>\n -0.127<\/td>\n 0.034<\/td>\n 1.88E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs8015085<\/td>\n 14<\/td>\n 93,585,331<\/td>\n ITPK1<\/td>\n a<\/td>\n g<\/td>\n 0.067<\/td>\n 0.008<\/td>\n 2.45E-18<\/td>\n -0.035<\/td>\n 0.008<\/td>\n 2.76E-05<\/td>\n -0.149<\/td>\n 0.042<\/td>\n 3.54E-04<\/td>\n 0.089<\/td>\n 0.031<\/td>\n 4.39E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs17477923<\/td>\n 15<\/td>\n 49,711,185<\/td>\n FAM227B<\/td>\n t<\/td>\n c<\/td>\n 0.083<\/td>\n 0.007<\/td>\n 2.57E-33<\/td>\n -0.036<\/td>\n 0.007<\/td>\n 1.01E-06<\/td>\n -0.245<\/td>\n 0.034<\/td>\n 6.15E-13<\/td>\n 0.071<\/td>\n 0.030<\/td>\n 1.66E-02<\/td>\n -0.064<\/td>\n 0.037<\/td>\n 8.14E-02<\/td>\n <\/tr>\n
rs11639111<\/td>\n 15<\/td>\n 49,749,735<\/td>\n FAM227B<\/td>\n t<\/td>\n c<\/td>\n 0.045<\/td>\n 0.006<\/td>\n 3.60E-13<\/td>\n -0.013<\/td>\n 0.007<\/td>\n 4.55E-02<\/td>\n -0.106<\/td>\n 0.032<\/td>\n 9.87E-04<\/td>\n 0.039<\/td>\n 0.026<\/td>\n 1.31E-01<\/td>\n -0.034<\/td>\n 0.031<\/td>\n 2.68E-01<\/td>\n <\/tr>\n
rs13329353<\/td>\n 15<\/td>\n 89,113,877<\/td>\n DET1<\/td>\n t<\/td>\n c<\/td>\n 0.061<\/td>\n 0.007<\/td>\n 5.17E-21<\/td>\n -0.032<\/td>\n 0.007<\/td>\n 3.68E-06<\/td>\n -0.094<\/td>\n 0.032<\/td>\n 3.37E-03<\/td>\n -0.008<\/td>\n 0.028<\/td>\n 7.88E-01<\/td>\n 0.021<\/td>\n 0.035<\/td>\n 5.50E-01<\/td>\n <\/tr>\n
rs1045476<\/td>\n 16<\/td>\n 4,015,313<\/td>\n ADCY9<\/td>\n a<\/td>\n g<\/td>\n 0.049<\/td>\n 0.008<\/td>\n 2.36E-09<\/td>\n -0.003<\/td>\n 0.009<\/td>\n 7.47E-01<\/td>\n -0.059<\/td>\n 0.043<\/td>\n 1.71E-01<\/td>\n 0.095<\/td>\n 0.033<\/td>\n 4.58E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs30227<\/td>\n 16<\/td>\n 14,405,428<\/td>\n MIR365A<\/td>\n t<\/td>\n c<\/td>\n -0.047<\/td>\n 0.006<\/td>\n 7.59E-14<\/td>\n 0.011<\/td>\n 0.007<\/td>\n 8.89E-02<\/td>\n 0.074<\/td>\n 0.033<\/td>\n 2.59E-02<\/td>\n -0.042<\/td>\n 0.026<\/td>\n 1.08E-01<\/td>\n 0.017<\/td>\n 0.044<\/td>\n 7.01E-01<\/td>\n <\/tr>\n
rs17767491<\/td>\n 16<\/td>\n 79,745,487<\/td>\n MAF<\/td>\n a<\/td>\n g<\/td>\n 0.088<\/td>\n 0.007<\/td>\n 3.35E-42<\/td>\n -0.013<\/td>\n 0.007<\/td>\n 5.56E-02<\/td>\n -0.164<\/td>\n 0.033<\/td>\n 7.25E-07<\/td>\n 0.077<\/td>\n 0.028<\/td>\n 5.56E-03<\/td>\n -0.154<\/td>\n 0.034<\/td>\n 5.21E-06<\/td>\n <\/tr>\n
rs77819282<\/td>\n 17<\/td>\n 44,762,589<\/td>\n NSF<\/td>\n a<\/td>\n g<\/td>\n 0.045<\/td>\n 0.007<\/td>\n 1.13E-09<\/td>\n -0.003<\/td>\n 0.008<\/td>\n 7.17E-01<\/td>\n -0.025<\/td>\n 0.039<\/td>\n 5.22E-01<\/td>\n 0.080<\/td>\n 0.030<\/td>\n 7.17E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1157994<\/td>\n 17<\/td>\n 59,338,574<\/td>\n BCAS3<\/td>\n a<\/td>\n g<\/td>\n -0.090<\/td>\n 0.016<\/td>\n 5.28E-09<\/td>\n -0.051<\/td>\n 0.017<\/td>\n 2.65E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1042673<\/td>\n 17<\/td>\n 70,121,339<\/td>\n SOX9<\/td>\n a<\/td>\n g<\/td>\n -0.055<\/td>\n 0.006<\/td>\n 3.57E-19<\/td>\n -0.003<\/td>\n 0.007<\/td>\n 6.67E-01<\/td>\n 0.151<\/td>\n 0.032<\/td>\n 3.25E-06<\/td>\n 0.004<\/td>\n 0.026<\/td>\n 8.74E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs963384<\/td>\n 17<\/td>\n 70,369,758<\/td>\n LINC00673<\/td>\n t<\/td>\n c<\/td>\n 0.035<\/td>\n 0.006<\/td>\n 2.77E-08<\/td>\n 0.003<\/td>\n 0.007<\/td>\n 6.48E-01<\/td>\n -0.183<\/td>\n 0.033<\/td>\n 2.66E-08<\/td>\n -0.030<\/td>\n 0.026<\/td>\n 2.49E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs4804413<\/td>\n 19<\/td>\n 7,222,655<\/td>\n INSR<\/td>\n t<\/td>\n c<\/td>\n 0.053<\/td>\n 0.006<\/td>\n 8.64E-18<\/td>\n -0.015<\/td>\n 0.007<\/td>\n 3.05E-02<\/td>\n -0.083<\/td>\n 0.032<\/td>\n 9.70E-03<\/td>\n 0.080<\/td>\n 0.026<\/td>\n 1.88E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1203944<\/td>\n 20<\/td>\n 22,596,879<\/td>\n FOXA2<\/td>\n t<\/td>\n c<\/td>\n -0.051<\/td>\n 0.007<\/td>\n 2.42E-12<\/td>\n 0.011<\/td>\n 0.008<\/td>\n 1.44E-01<\/td>\n 0.078<\/td>\n 0.038<\/td>\n 3.80E-02<\/td>\n -0.127<\/td>\n 0.032<\/td>\n 6.08E-05<\/td>\n 0.053<\/td>\n 0.039<\/td>\n 1.82E-01<\/td>\n <\/tr>\n
rs12390237<\/td>\n 23<\/td>\n 3,612,081<\/td>\n PRKX<\/td>\n a<\/td>\n g<\/td>\n -0.046<\/td>\n 0.007<\/td>\n 1.74E-11<\/td>\n 0.003<\/td>\n 0.007<\/td>\n 7.08E-01<\/td>\n 0.093<\/td>\n 0.036<\/td>\n 1.00E-02<\/td>\n -0.014<\/td>\n 0.032<\/td>\n 6.61E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n

free T4<\/b><\/td>\n 		<\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/tr>\n
SNP<\/td>\n Chr<\/td>\n Position (hg19)<\/td>\n Nearest Gene<\/td>\n A1<\/td>\n A2<\/td>\n BETA<\/td>\n SE<\/td>\n P<\/td>\n BETA TSH<\/td>\n SE TSH<\/td>\n P TSH<\/td>\n BETA hyperthyroidism<\/td>\n SE hyperthyroidism<\/td>\n P hyperthyroidism<\/td>\n BETA hypothyroidism<\/td>\n SE hypothyroidism<\/td>\n P hypothyroidism<\/td>\n BETA TPOab-positivity<\/td>\n SE TPOab-positivity<\/td>\n P TPOab-positivity<\/td>\n <\/tr>\n
rs145019385<\/td>\n 1<\/td>\n 54,252,139<\/td>\n TMEM48<\/td>\n t<\/td>\n c<\/td>\n 0.181<\/td>\n 0.032<\/td>\n 1.13E-08<\/td>\n -0.012<\/td>\n 0.031<\/td>\n 7.09E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs12033572<\/td>\n 1<\/td>\n 54,369,674<\/td>\n DIO1<\/td>\n c<\/td>\n g<\/td>\n 0.115<\/td>\n 0.017<\/td>\n 1.45E-11<\/td>\n -0.015<\/td>\n 0.017<\/td>\n 3.76E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n 0.026<\/td>\n 0.103<\/td>\n 7.97E-01<\/td>\n <\/tr>\n
rs2235544<\/td>\n 1<\/td>\n 54,375,570<\/td>\n DIO1<\/td>\n a<\/td>\n c<\/td>\n 0.139<\/td>\n 0.007<\/td>\n 4.20E-101<\/td>\n -0.012<\/td>\n 0.006<\/td>\n 6.33E-02<\/td>\n 0.021<\/td>\n 0.031<\/td>\n 5.07E-01<\/td>\n -0.013<\/td>\n 0.025<\/td>\n 6.13E-01<\/td>\n -0.039<\/td>\n 0.027<\/td>\n 1.52E-01<\/td>\n <\/tr>\n
rs954878<\/td>\n 1<\/td>\n 54,578,401<\/td>\n TCEANC2<\/td>\n a<\/td>\n g<\/td>\n -0.058<\/td>\n 0.007<\/td>\n 4.83E-19<\/td>\n -0.002<\/td>\n 0.006<\/td>\n 8.00E-01<\/td>\n 0.015<\/td>\n 0.031<\/td>\n 6.22E-01<\/td>\n -0.030<\/td>\n 0.025<\/td>\n 2.30E-01<\/td>\n 0.030<\/td>\n 0.028<\/td>\n 2.97E-01<\/td>\n <\/tr>\n
rs4954192<\/td>\n 2<\/td>\n 135,632,981<\/td>\n ACMSD<\/td>\n t<\/td>\n c<\/td>\n -0.041<\/td>\n 0.007<\/td>\n 8.38E-09<\/td>\n -0.006<\/td>\n 0.006<\/td>\n 3.33E-01<\/td>\n 0.066<\/td>\n 0.033<\/td>\n 4.45E-02<\/td>\n -0.009<\/td>\n 0.026<\/td>\n 7.46E-01<\/td>\n 0.038<\/td>\n 0.031<\/td>\n 2.23E-01<\/td>\n <\/tr>\n
rs6785807<\/td>\n 3<\/td>\n 181,718,601<\/td>\n SOX2-OT<\/td>\n a<\/td>\n g<\/td>\n -0.059<\/td>\n 0.009<\/td>\n 2.47E-10<\/td>\n -0.009<\/td>\n 0.009<\/td>\n 2.96E-01<\/td>\n 0.085<\/td>\n 0.043<\/td>\n 4.81E-02<\/td>\n 0.016<\/td>\n 0.036<\/td>\n 6.53E-01<\/td>\n -0.014<\/td>\n 0.050<\/td>\n 7.81E-01<\/td>\n <\/tr>\n
rs6854291<\/td>\n 4<\/td>\n 170,992,760<\/td>\n AADAT<\/td>\n a<\/td>\n g<\/td>\n 0.117<\/td>\n 0.011<\/td>\n 1.35E-24<\/td>\n 0.023<\/td>\n 0.011<\/td>\n 3.01E-02<\/td>\n 0.051<\/td>\n 0.055<\/td>\n 3.58E-01<\/td>\n 0.024<\/td>\n 0.043<\/td>\n 5.85E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10946313<\/td>\n 6<\/td>\n 19,381,386<\/td>\n ID4<\/td>\n t<\/td>\n c<\/td>\n 0.046<\/td>\n 0.007<\/td>\n 2.28E-11<\/td>\n 0.020<\/td>\n 0.006<\/td>\n 1.97E-03<\/td>\n 0.027<\/td>\n 0.032<\/td>\n 4.07E-01<\/td>\n 0.028<\/td>\n 0.026<\/td>\n 2.82E-01<\/td>\n 0.015<\/td>\n 0.045<\/td>\n 7.38E-01<\/td>\n <\/tr>\n
rs9356988<\/td>\n 6<\/td>\n 25,777,481<\/td>\n SLC17A4<\/td>\n a<\/td>\n g<\/td>\n -0.051<\/td>\n 0.007<\/td>\n 3.56E-12<\/td>\n 0.002<\/td>\n 0.007<\/td>\n 8.05E-01<\/td>\n 0.028<\/td>\n 0.034<\/td>\n 4.10E-01<\/td>\n 0.033<\/td>\n 0.028<\/td>\n 2.33E-01<\/td>\n -0.009<\/td>\n 0.036<\/td>\n 7.94E-01<\/td>\n <\/tr>\n
rs137964359<\/td>\n 6<\/td>\n 26,001,742<\/td>\n TRIM38<\/td>\n t<\/td>\n c<\/td>\n -0.200<\/td>\n 0.032<\/td>\n 2.13E-10<\/td>\n 0.030<\/td>\n 0.031<\/td>\n 3.35E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs17185536<\/td>\n 6<\/td>\n 100,620,931<\/td>\n LOC728012<\/td>\n t<\/td>\n c<\/td>\n 0.073<\/td>\n 0.008<\/td>\n 1.93E-19<\/td>\n 0.003<\/td>\n 0.008<\/td>\n 7.09E-01<\/td>\n -0.029<\/td>\n 0.038<\/td>\n 4.43E-01<\/td>\n -0.028<\/td>\n 0.031<\/td>\n 3.66E-01<\/td>\n 0.031<\/td>\n 0.039<\/td>\n 4.27E-01<\/td>\n <\/tr>\n
rs67583169<\/td>\n 8<\/td>\n 61,212,179<\/td>\n CA8<\/td>\n c<\/td>\n g<\/td>\n 0.061<\/td>\n 0.010<\/td>\n 9.99E-11<\/td>\n -0.012<\/td>\n 0.009<\/td>\n 1.69E-01<\/td>\n -0.110<\/td>\n 0.043<\/td>\n 1.11E-02<\/td>\n -0.033<\/td>\n 0.035<\/td>\n 3.48E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10119187<\/td>\n 9<\/td>\n 4,223,660<\/td>\n GLIS3<\/td>\n t<\/td>\n c<\/td>\n 0.050<\/td>\n 0.009<\/td>\n 4.11E-09<\/td>\n -0.037<\/td>\n 0.008<\/td>\n 2.34E-06<\/td>\n 0.062<\/td>\n 0.041<\/td>\n 1.29E-01<\/td>\n -0.105<\/td>\n 0.033<\/td>\n 1.39E-03<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10739496<\/td>\n 9<\/td>\n 100,552,559<\/td>\n FOXE1<\/td>\n t<\/td>\n c<\/td>\n 0.078<\/td>\n 0.007<\/td>\n 4.20E-30<\/td>\n 0.032<\/td>\n 0.006<\/td>\n 5.73E-07<\/td>\n 0.186<\/td>\n 0.033<\/td>\n 1.88E-08<\/td>\n 0.245<\/td>\n 0.027<\/td>\n 2.41E-19<\/td>\n 0.032<\/td>\n 0.033<\/td>\n 3.37E-01<\/td>\n <\/tr>\n
rs10984606<\/td>\n 9<\/td>\n 100,739,117<\/td>\n ANP32B<\/td>\n t<\/td>\n g<\/td>\n -0.040<\/td>\n 0.007<\/td>\n 1.17E-09<\/td>\n -0.013<\/td>\n 0.006<\/td>\n 3.05E-02<\/td>\n -0.078<\/td>\n 0.032<\/td>\n 1.48E-02<\/td>\n -0.061<\/td>\n 0.025<\/td>\n 1.47E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs10818937<\/td>\n 9<\/td>\n 127,015,440<\/td>\n NEK6<\/td>\n t<\/td>\n c<\/td>\n -0.048<\/td>\n 0.007<\/td>\n 1.31E-11<\/td>\n 0.022<\/td>\n 0.007<\/td>\n 6.02E-04<\/td>\n -0.017<\/td>\n 0.035<\/td>\n 6.25E-01<\/td>\n 0.080<\/td>\n 0.027<\/td>\n 3.46E-03<\/td>\n 0.011<\/td>\n 0.033<\/td>\n 7.47E-01<\/td>\n <\/tr>\n
rs4842131<\/td>\n 9<\/td>\n 139,092,679<\/td>\n LHX3<\/td>\n t<\/td>\n c<\/td>\n -0.104<\/td>\n 0.008<\/td>\n 7.68E-44<\/td>\n -0.007<\/td>\n 0.007<\/td>\n 3.10E-01<\/td>\n 0.010<\/td>\n 0.035<\/td>\n 7.67E-01<\/td>\n 0.007<\/td>\n 0.028<\/td>\n 8.10E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs55679545<\/td>\n 9<\/td>\n 139,122,363<\/td>\n QSOX2<\/td>\n a<\/td>\n g<\/td>\n 0.044<\/td>\n 0.008<\/td>\n 8.42E-09<\/td>\n -0.007<\/td>\n 0.007<\/td>\n 3.24E-01<\/td>\n 0.018<\/td>\n 0.037<\/td>\n 6.36E-01<\/td>\n -0.023<\/td>\n 0.030<\/td>\n 4.37E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs11039355<\/td>\n 11<\/td>\n 47,737,501<\/td>\n FNBP4<\/td>\n t<\/td>\n c<\/td>\n -0.039<\/td>\n 0.007<\/td>\n 3.51E-08<\/td>\n -0.002<\/td>\n 0.007<\/td>\n 7.58E-01<\/td>\n -0.046<\/td>\n 0.033<\/td>\n 1.70E-01<\/td>\n 0.099<\/td>\n 0.027<\/td>\n 2.22E-04<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs4149056<\/td>\n 12<\/td>\n 21,331,549<\/td>\n SLCO1B1<\/td>\n t<\/td>\n c<\/td>\n -0.051<\/td>\n 0.009<\/td>\n 1.34E-08<\/td>\n 0.014<\/td>\n 0.008<\/td>\n 9.17E-02<\/td>\n -0.043<\/td>\n 0.045<\/td>\n 3.31E-01<\/td>\n -0.031<\/td>\n 0.036<\/td>\n 3.87E-01<\/td>\n -0.022<\/td>\n 0.047<\/td>\n 6.43E-01<\/td>\n <\/tr>\n
rs150816132<\/td>\n 14<\/td>\n 80,464,293<\/td>\n NRXN3<\/td>\n a<\/td>\n g<\/td>\n -0.220<\/td>\n 0.040<\/td>\n 3.47E-08<\/td>\n -0.029<\/td>\n 0.037<\/td>\n 4.35E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs978055<\/td>\n 14<\/td>\n 80,534,869<\/td>\n DIO2<\/td>\n a<\/td>\n t<\/td>\n 0.038<\/td>\n 0.007<\/td>\n 1.06E-08<\/td>\n -0.003<\/td>\n 0.006<\/td>\n 6.45E-01<\/td>\n -0.029<\/td>\n 0.032<\/td>\n 3.71E-01<\/td>\n -0.004<\/td>\n 0.026<\/td>\n 8.88E-01<\/td>\n 0.025<\/td>\n 0.030<\/td>\n 4.13E-01<\/td>\n <\/tr>\n
rs225014<\/td>\n 14<\/td>\n 80,669,580<\/td>\n DIO2<\/td>\n t<\/td>\n c<\/td>\n 0.054<\/td>\n 0.007<\/td>\n 1.83E-15<\/td>\n 0.017<\/td>\n 0.006<\/td>\n 6.64E-03<\/td>\n -0.037<\/td>\n 0.033<\/td>\n 2.58E-01<\/td>\n 0.027<\/td>\n 0.027<\/td>\n 3.17E-01<\/td>\n 0.028<\/td>\n 0.032<\/td>\n 3.79E-01<\/td>\n <\/tr>\n
rs12323871<\/td>\n 14<\/td>\n 101,852,075<\/td>\n DIO3OS<\/td>\n t<\/td>\n c<\/td>\n -0.047<\/td>\n 0.008<\/td>\n 1.42E-08<\/td>\n -0.012<\/td>\n 0.008<\/td>\n 1.45E-01<\/td>\n -0.016<\/td>\n 0.039<\/td>\n 6.81E-01<\/td>\n 0.011<\/td>\n 0.033<\/td>\n 7.43E-01<\/td>\n 0.005<\/td>\n 0.065<\/td>\n 9.44E-01<\/td>\n <\/tr>\n
rs11626434<\/td>\n 14<\/td>\n 101,998,443<\/td>\n DIO3OS<\/td>\n c<\/td>\n g<\/td>\n 0.058<\/td>\n 0.007<\/td>\n 4.08E-17<\/td>\n 0.006<\/td>\n 0.007<\/td>\n 3.47E-01<\/td>\n -0.019<\/td>\n 0.035<\/td>\n 5.94E-01<\/td>\n 0.042<\/td>\n 0.028<\/td>\n 1.27E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs12907106<\/td>\n 15<\/td>\n 63,873,658<\/td>\n USP3<\/td>\n c<\/td>\n g<\/td>\n -0.041<\/td>\n 0.007<\/td>\n 3.67E-08<\/td>\n 0.005<\/td>\n 0.007<\/td>\n 4.96E-01<\/td>\n 0.040<\/td>\n 0.035<\/td>\n 2.45E-01<\/td>\n 0.008<\/td>\n 0.029<\/td>\n 7.85E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs8063103<\/td>\n 16<\/td>\n 12,703,395<\/td>\n SNX29<\/td>\n c<\/td>\n g<\/td>\n -0.052<\/td>\n 0.009<\/td>\n 1.61E-08<\/td>\n 0.001<\/td>\n 0.009<\/td>\n 9.35E-01<\/td>\n -0.003<\/td>\n 0.045<\/td>\n 9.43E-01<\/td>\n 0.040<\/td>\n 0.037<\/td>\n 2.68E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs11078333<\/td>\n 17<\/td>\n 16,049,626<\/td>\n NCOR1<\/td>\n a<\/td>\n t<\/td>\n 0.051<\/td>\n 0.007<\/td>\n 9.91E-13<\/td>\n -0.002<\/td>\n 0.007<\/td>\n 7.43E-01<\/td>\n -0.003<\/td>\n 0.034<\/td>\n 9.24E-01<\/td>\n -0.051<\/td>\n 0.028<\/td>\n 6.97E-02<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs1080094<\/td>\n 18<\/td>\n 29,173,795<\/td>\n TTR<\/td>\n a<\/td>\n g<\/td>\n -0.042<\/td>\n 0.007<\/td>\n 4.06E-10<\/td>\n 0.007<\/td>\n 0.006<\/td>\n 2.73E-01<\/td>\n 0.022<\/td>\n 0.032<\/td>\n 5.00E-01<\/td>\n -0.015<\/td>\n 0.026<\/td>\n 5.64E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs113107469<\/td>\n 18<\/td>\n 29,306,737<\/td>\n SLC25A52<\/td>\n t<\/td>\n c<\/td>\n 0.200<\/td>\n 0.022<\/td>\n 1.00E-19<\/td>\n 0.013<\/td>\n 0.020<\/td>\n 5.09E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
rs56069042<\/td>\n 18<\/td>\n 57,914,644<\/td>\n MC4R<\/td>\n a<\/td>\n g<\/td>\n 0.106<\/td>\n 0.019<\/td>\n 1.16E-08<\/td>\n 0.012<\/td>\n 0.018<\/td>\n 4.99E-01<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n NA<\/td>\n <\/tr>\n
<\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/tr>\n<\/table>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Genome-wide significant GWAS associations of the Teumer et al. (Nat Commun., 2018) dataset for the free T4 and TSH levels with the corresponding association results of additional traits added. The TPOab-positivity results are from the Medici et al. (PLoS Genetics, 2014) publication. TSH SNP Chr Position (hg19) Nearest Gene A1 A2 BETA SE P BETA … <\/p>\n

Continue reading “Genetic Associations”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-110","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/pages\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/comments?post=110"}],"version-history":[{"count":19,"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/pages\/110\/revisions"}],"predecessor-version":[{"id":144,"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/pages\/110\/revisions\/144"}],"wp:attachment":[{"href":"https:\/\/genepi.med.uni-greifswald.de\/thyroidomics\/wp-json\/wp\/v2\/media?parent=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}